Turkey Tail Mushrooms – Powerful Medicine

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Turkey tail is one of a variety of mushrooms that have been used for medicinal purposes for centuries in Asia.

Also known as Trametes versicolor or Coriolus versicolor, it got its nickname because its vivid color patterns that appear similar to that of, yes, a turkey’s tail.

And while turkey tail mushrooms are purported to have numerous health benefits, one that particularly stands out is its reputation for boosting the immune system to fight off cancer.

What are the potential health benefits of turkey tail mushrooms?

You might spot one of these colorful mushrooms, which can resemble a series of discs, growing out of the side of a hardwood tree. They’re very common in the United States, and they’re pretty hardy, too.

Why do these multicolored mushrooms seem to hold so much promise? Turkey tail mushroom enthusiasts note that these mushrooms have numerous properties that benefit your immune system.


For example, turkey tail mushrooms are high in antioxidantsTrusted Source like phenols. Antioxidants reduce or inhibit cellular damage caused by oxidative stress, a condition caused by an imbalance between antioxidants and reactive molecules called free radical molecules.

And turkey tails don’t just have high levels of antioxidants — they seem to have numerous different kinds. In fact, one 2017 studyTrusted Source found that turkey tail mushrooms have 35 different phenolic compounds.


They also contain polysaccharopeptides, including krestin (PSK) and polysaccharide peptide (PSP), which may help boost your body’s immune system. As you’ll see, that’s one reason so many people are interested in this mushroom’s potential role in fighting cancer.

What types of cancer might turkey tail mushrooms help fight?

Researchers continue to examine the potential of using extract or treatments derived from turkey tail mushrooms to prevent or treat several kinds of cancer.

Although some study results are promising, turkey tail can’t replace anticancer drugs. They should only be used by people with cancer if recommended by their oncologist.

Breast cancer

Women undergoing treatment for breast cancer might benefit from turkey tail mushroom agents.

In fact, a 2008 reviewTrusted Source called for more research on the potential of turkey tail mushroom and its PSK for breast cancer. It was proposed as add-on immunotherapy therapy that you’d take after primary breast cancer treatment, like surgery or chemotherapy.

A 2012 study followed up on this call for research. The study was small, with only nine participants. However, the researchers found that a daily oral preparation containing Trametes versicolor powder improved immune status after standard treatment for breast cancer.

Additionally, they found that the preparation was well tolerated by the participants in the study.


While more research is needed, an in vitro 2013 study published in 2013 showed promise in using an extract derived from turkey tail mushrooms in treating leukemia.

The researchers studied the effect of an extract taken from Trametes versicolor mushrooms treat leukemia cells. They compared its use alone versus a combination of Trametes versicolor and Ganoderma lucidum, or reishi mushroom.

The researchers found that the combination was more potent than Trametes versicolor alone. They think this may be because the two different mushrooms affect different biological processes.

This combination may help cancer patients on a broader level. In one 2019 studyTrusted Source, a team of researchers reviewed 23 clinical trials involving more than 4,200 patients.

They found that products containing these two mushrooms may indeed improve both survival and quality of life for some people with certain types of cancer, including breast, lung, and gastrointestinal cancers.

Colon cancer

Another study that looked at the use of extracts derived from two types of mushrooms, including turkey tail mushrooms, found promise in treating colon cancer cells.

One 2019 studyTrusted Source examined the effects of using Trametes versicolor and Grifola frondosa, which is perhaps better known as the maitake or hen-of-the-woods mushroom.

Together, the two mushroom extracts demonstrated the ability to stop cancer cells from spreading. The researchers also found the two extracts together could even enhance the effectiveness of a drug often used to treat colorectal cancers, 5-fluorouracil.

Lung cancer

A 2015 review of 11 clinical trials and an additional 17 preclinical studies found that using PSK from the Trametes versicolor mushrooms helped lung cancer patients who underwent radiation treatment live longer.

The extract also seemed to improve other aspects of the patients’ progress, including body weight, immune function, and quality of life.

Other cancers

People living with other cancers may benefit from turkey tail mushrooms, too. For example, a review of eight studiesTrusted Source that included more than 8,000 people with gastric cancer found that adding PSK to their chemotherapy helped them live longer.

However, not all of the research has been quite so enrcouraging. One recent studyTrusted Source reported that an agent containing both Trametes versicolor and Grifola frondose wasn’t effective at controlling the spread of colon cancer cells in the lab. More research is needed.

Are there any possible side effects?

While they’re generally considered safe, turkey tail mushrooms can occasionally have a few side effects to be aware of, including:

  • digestive upset, such as diarrhea, gas, or bloating
  • darker pigment in your fingernails

(SOURCE: Jennifer Larson)

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