The 1665 Plague#MoreLikeThisPlease, Health, History, Science, Smart The 1665 Plague When Isaac Newton stayed at home to avoid the 1665 Plague, he discovered the Laws of Gravity, Optics and invented Calculus. SHARE ON TwitterFacebookBufferLinkedInPin ItSpread the lovepreviousSleeping PodsnextDo not pet the fluffy cows